Pathophysiology of metalloproteinase matrix in relation to morbid obesity and associated pathologies

Matrix Metalloproteinases (MMPs), these calcium-dependent zinc-containing endopeptidases play an important role in adipogenesis and angiogenesis by modifying tissues degrading the extracellular matrix (ECM). glycoproteins, gelatin, collagens, proteoglycans elastin are all found ECM. Current meta-analysis confirmed lower levels of IL-6 CRP was following bariatric surgery. Several studies have shown correlations between E-selectin levels, BMI, MMP-9 levels. There also a strong link metalloproteinases MMP-2 MMP-9. adiponectin related. on other hand, were modestly linked with HDL cholesterol as previously stated. Also current observations imply that alterations ECM caused MMP-mediated degradation may be crucial for differentiation adipocytes. The most component this is MMPs involved remodeling tissue after gastric bypass surgery, revealed markers (especially MMP-9). Thus, it tempting to assume adipocyte derived constitute novel pharmaceutical target limiting adipose development through reduction angiogenesis. exhibits far more accurate oscillations than during pre- post-surgical weight fluctuations, hence used predictor success. purpose paper conduct comprehensive review literature emphasis critical functions pathophysiology obesity related diseases.